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ea0081ep262 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Evolution of combined impaired fasting glucose and impaired glucose tolerance in 58 β-thalassemia major (β-TM) patients during a mean 7.7 year follow-up

Sanctis Vincenzo De , Daar Shahina , Soliman Ashraf , Tzoulis Ploutarchos , Yassin Mohamed , Kattamis Christos

Background: In patients with β- thalassemia major (β-TM) glucose dysregulation (GD) develops insidiously, aggravating prognosis and quality of life.Objectives: The objectives of this study were to retrospectively review the extent to which β-TM patients, having combined impaired fasting glucose (IFG) and impaired glucose tolerance test (IGT) on oral glucose tolerance test (OGTT), progressed to diabetes (DM) and to analyze ...

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ea0081ep278 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Evolution of glucose-insulin homeostasis in children with β - thalassemia major (β -TM): A twenty-year retrospective ICET- A observational analysis from early childhood to young adulthood

Sanctis Vincenzo De , Daar Shahina , Soliman Ashraf , Tzoulis Ploutarchos , Karimi Mehran , Kattamis Christos

We studied retrospectively the changes of glucose-insulin homeostasis from early childhood to young adulthood in β-thalassemia major (β -TM) patients with impaired fasting glucose (IFG) vs those with normal OGTT.Methods: All data entered in the database of β -TM patients records from September 1983 to September 2021 were included in the study.Results: The occurrence of dysglycemia (GD)...

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ea0081ep288 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Surrogate measures of insulin secretion and sensitivity (IS) in young children with beta thalassemia major on repeated blood transfusion and iron chelation therapy.

Sanctis Vincenzo De , Daar Shahina , Soliman Ashraf , Tzoulis Ploutarchos , Karimi Mehran , Kattamis Christos

We assessed glycemia and insulin markers in 18 young children with beta thalassemia major (BTM). Insulin markers measured included: the Homeostatic Model Assessment index of insulin resistance (HOMA-IR), Matsuda index (MI), the insulinogenic index (IGI), and the oral disposition index (oDI). 9 had normal fasting glucose (FG) and 9 had impaired fasting glucose (IFG)Results: HOMA-IR, a marker of IR was significantly higher in children with BTM compared to ...

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Endocrine Abstracts

Evolution of combined impaired fasting glucose and impaired glucose tolerance in 58 β-thalassemia major (β-TM) patients during a mean 7.7 year follow-up

Evolution of glucose-insulin homeostasis in children with β - thalassemia major (β -TM): A twenty-year retrospective ICET- A observational analysis from early childhood to young adulthood

Surrogate measures of insulin secretion and sensitivity (IS) in young children with beta thalassemia major on repeated blood transfusion and iron chelation therapy.

BiosciAbstracts